Drug metabolism in drug discovery and development

Ethnobotany, Ethnopharmacology and Drug Discovery

     This manuscript is a review of a number of ethnobotany and ethnopharmacology texts and papers in order to arrive at current understanding and scope of ethnobotany and ethnopharmacology. It includes either a brief definition of both fields and presenting some examples on them. Also it has a glimpse on the geographical coverage of research works throughout the world, important issue of prope...

Role of pharmacokinetics and metabolism in drug discovery and development.

Role of Xenobiotic Metabolism in Drug Discovery and Development

New horizons in drug metabolism, pharmacokinetics and drug discovery.

Along with minimal toxicity, good drug metabolism and pharmacokinetic (DMPK) properties are essential for the clinical success of a drug candidate. A major cause of failure of orally administered drugs during their development is the discovery that in humans they have low intestinal absorption and/or high clearance causing low and variable bioavailability. In addition, drug interactions and the...

Drug discovery and development: India

Implementation period CDRI was established in 1951 and has pursued various broad-based and long-term drug development projects over the ensuing five decades.This approach has led to the development of a pipeline of products from natural resources, including the commercialization of at least five lead compounds or products: gugulipid (hypolipidaemic), Bacopa monniera standardized fraction (memor...